Anxiety and the Endocannabinoid System

Anxiety is a normal coping mechanism; however, in excess, it can be detrimental. More than just a situational response, anxiety disorders are characterized by a persistent and oftentimes irrational dread of everyday situations which can interfere with daily activities.

Forty million U.S. adults are affected by an anxiety-related disorder; however, the prevalence of these disorders should not diminish their impact.

Excessive anxiety is a central symptom of several neuropsychiatric disorders including generalized anxiety disorder (GAD), panic disorder (PD), post-traumatic stress disorder (PTSD), and obsessive-compulsive disorder (OCD). Anxiety is a complex disorder that can develop through various factors including genetics, brain chemistry, personality, and life events.

Anxiety and Emotional Response

Anxiety is our body’s response to an emotional situation. Biologically, anxiety activates our “fight or flight” response to warn us of potential threats.

During such time, norepinephrine and cortisol flood our system to boost to perception, reflexes, and speed. These chemicals increase the heart rate, blood flow to the muscles, and air flow. With chronic anxiety, the response is never deactivated, and the physical and emotional effects of anxiety remain.

Anxiety and the Endocannabinoid System

The endocannabinoid system (ECS) plays an integral role in regulating emotional response.

Specifically, the ECS supports nerve activity that determines our response to emotional or aversive events.

An Introduction to the ECS

As discussed in a previous blog, the endocannabinoid system is a biological system responsible for maintaining homeostasis. The ECS is composed of endocannabinoids, degradative enzymes, and cannabinoid receptors. Endocannabinoids such as anandamide (“the bliss molecule”) and 2-arachidonoylglycerol (2AG) are synthesized, or created, by our body on demand in response to an imbalance. They interact with the cannabinoid receptors to direct the body back to proper functioning.

CB1 Receptors and Anxiety

CB1 receptors, which are primarily located on nerve endings, are one of the two major cannabinoid receptors.

Studies have found the activation of the CB1 receptor produces anxiolytic (anti-anxiety) effects.

When discussing conditioned fear, the effect of CB1 receptor activation is complex; however, CB1 receptor activation can reduce fear and prevent the activation of existing memories from the past. Additionally, CB1 receptor activation protects against the adverse effects of chronic stress, which can lead to anxiety. For this reason, CB1 receptor activation has been studied for anxiolytic drug development.

Endocannabinoids activate the CB1 receptor; therefore, a higher level of endocannabinoids can be beneficial for those with anxiety-related disorders. Additionally, chemicals that inhibit the FAAH enzyme from breaking down anandamide increase endocannabinoid availability and are also being studied for their anxiolytic effects.

Living with Anxiety

There are many ways to manage anxiety; however, less than 40% of those with an anxiety disorder seek treatment. Still today, there is a stigma surrounding mental illness that discourages those struggling from seeking help. We can help end the stigma of mental illness by having open conversations about mental health, encouraging mental health education, and showing compassion to those with a mental illness.

If you or a loved one is struggling with an anxiety disorder, we encourage you to learn more about the disorder and the options for treatment.

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Careers For People Who Love Sports

If you’re going to spend your time working at a job, it may as well be related to something that you love, right? Too many people disconnect their passion from their work — they think that a job is something you’re not supposed to enjoy. Of course, it can be that way, but that doesn’t mean that it should be. It’s worthwhile taking the time to find a job you love, and your passion is a good place to start looking. If your passion is sport, then read on, where we outline a few sports-related careers that any fanatic would love to have as their job.


Down the Coaching Route

OK, so there’s every chance that you won’t quite make it as a professional athlete. Even if you were far and away the best athlete in your school, the chances are still tiny! But that doesn’t mean that you can’t be involved with the best of the best. They say that those who can’t do, teach — so teach. There’s much fun and satisfaction to be had in coaching, whether it be working with youngsters trying to find their way or the top-end professionals. Give it a go: you might just find that you find your life’s work.

Keeping Up With Fitness

The great thing about sports is that it covers a wide range of activities. It’s not just professional games; it’s the individual, the gym membership, the quest to be better. If this latter point is one of the reasons why you love sports, then why not look at becoming a personal trainer? You’ll work with people to help them to achieve their fitness goals, whatever they may be. It can be a well-paying gig, but you won’t be in it for the money. The satisfaction of knowing that you helped someone become the best version of themselves will be enough.

Around the Big Games

But of course, it gets no better than the top-end, professional sports. When there’s a big game rolling around, the buzz is intoxicating: this is where people who love the excitement of sports want to be. While it’s unlikely you’ll end up on the field (though becoming an official could be one way…), there are other ways to be involved. One is to make the most of Pay Per Head 24/7 Bookmaking Services, and become a sports betting agent. Another is to become a reporter for the game, either by writing a report or making videos outside the ground.

Behind the Scenes

But let’s say you don’t want to exist on the fringes of the big game, but somewhere in the fire itself. One route is to get involved in the behind the scenes planning and organization. You might not have thought of it, but there’s much that goes into organizing a large game! You could work in logistics, hospitality, security, television, or anything else. So long as you’re to be found somewhere within the stadium on match day, you’re not going to have too many complaints.

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Pros & Cons Of Having A Fleet Of Vehicles For Your Small Business

Will a fleet of vehicles benefit your business? Source

Are you thinking about getting a fleet of vehicles for your business? If you run any sort of company that involves moving around to different places, then it could definitely benefit you. Delivery companies, service-based businesses – and many more – could all make use of a fleet of vehicles.

But, is this the right decision for you? To help you out, here are the pros and cons:

Pro: Expand your service

The obvious advantage of a fleet is that you can expand your service. You can send out employees to different areas of the country, and the fleet means you can service more people at one time. When you operate on your own – or only use one or two vehicles – then it restricts what you’re capable of. Having a fleet opens up new business opportunities!

Con: Risk of accidents

If you hire a fleet of vehicles, then you also get the risks that come with it. The main one revolves around auto accidents, which are more likely when you have multiple vehicles to manage. The problem is, other people can cause auto accidents which set your business back. As such, a lot of your time is devoted to fleet accident management, so you know what to do if the worst happens. By all means, you might never have to deal with this issue. But, it’s a cause for concern because the risks are greater than if you didn’t have a fleet.

Pro: Free advertising

When you get your fleet, you can put your brand logo and contact information on them. Essentially, the vehicles now have decals that advertise your business for you. So, whenever your team is driving around, they’re promoting the business for free! It’s a very smart way of finding new customers and growing your business even further.

Fleet management can be an accounting nightmare. Source

Con: Expensive to manage

Unsurprisingly, a fleet of vehicles isn’t cheap to manage. You have the initial cost of hiring the fleet, and then you have the general running costs too. Think about insurance, fuel, and then regular maintenance. All these things add up, and it can be far too expensive for some small businesses. Instead, you might be better off hiring a team and ensuring that they provide their own vehicle. You lose the advertising benefits that a fleet brings, but you cut the costs quite dramatically.

When you start weighing up the pros and cons, you realize that your small business might not be suited to hiring a fleet of vehicles. Likewise, you may feel as though the pros outweigh the cons, and it would be beneficial to have a fleet. Ultimately, it all depends on your company. If you have the money to hire and manage a fleet, then it will definitely bring lots of benefits. You can grow your business and reach more clients, which helps boost your sales figures. Over time, the increased sales can help deal with the management costs – and then some. But, if you don’t have the financial capacity to do so, then it could be better to hold off and wait until you do. Hopefully, this post has given you a deeper look at having a fleet, so you can decide if it’s worth it or not for your small business!

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